2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W664824
    Desalkylquazepam 1645-32-5 98%
    Desalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines. Desalkylquazepam is a mAChR modulator (EC 50 = 0.317 µM).
    Desalkylquazepam
  • HY-W665208
    Zapotin 14813-19-5 98%
    Zapotin is a member of the polymethoxyflavones, which are natural polyphenols from the group of flavonoid. Zapotin exhibits antidepressant, anticancer, antifungal, and antioxidant activity. Zapotin is a chemopreventive and chemotherapeutic agent. Zapotin can result in a reduction of large aberrant crypt foci in CF-1 mouse model. Zapotin inhibits autophagosome formation. Zapotin has inhibitory activity in mouse mammary organ culture with an IC50 of 50 µg/mL.
    Zapotin
  • HY-W679138
    N,N-dimethyldithiocarbamate potassium 128-03-0 98%
    N,N-dimethyldithiocarbamate potassium is a ubiquitin-activating enzyme E1 inhibitor. N,N-dimethyldithiocarbamate potassium inhibits the activation of E1 and reduces the level of activated ubiquitinated E1 (ub-E1). N,N-dimethyldithiocarbamate potassium increases intracellular copper levels, enhances oxidative stress, elevates protein carbonyl levels, and upregulates the expression of HO-1. N,N-dimethyldithiocarbamate potassium is applicable to research related to Parkinson's disease.
    N,N-dimethyldithiocarbamate potassium
  • HY-W680647
    MDL 72527 free base 99207-33-7 98%
    MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects.
    MDL 72527 free base
  • HY-W680961
    Hydrohydrastinine 494-55-3 98%
    Hydrohydrastinine is a selective α4β2 nicotinic acetylcholine receptor antagonist with an IC50 of 2.6 μM and a Ki of 17 μM. Hydrohydrastinine exhibits weak activity at α4β4 and α3β4 nicotinic acetylcholine receptors. Hydrohydrastinine can be used for the research of depression.
    Hydrohydrastinine
  • HY-W681014
    5-Fluoro-α-methyltryptamine hydrochloride 776-56-7 98%
    5-Fluoro-α-methyltryptamine hydrochloride may cause an increase in intracellular levels of 5-HT followed by an increase in 5-HT release. 5-Fluoro-α-methyltryptamine hydrochloride exhibits EC50 values of 37 nM, 14 nM, 78 nM and 8.47 nM for DA, 5HT, NE and 5-HT2A, respectively.
    5-Fluoro-α-methyltryptamine hydrochloride
  • HY-W681071
    BRS-3 receptor agonist-2 1021937-07-4 98%
    BRS-3 receptor agonist-2 (compound 2) is a potent BRS-3 receptor agonist, with an EC50 of 2.5 nM for mouse BRS-3 receptor.
    BRS-3 receptor agonist-2
  • HY-W681674
    para-Methylaminorex 959249-62-8 98%
    para-Methylaminorex is structurally similar to known stimulants.
    para-Methylaminorex
  • HY-W683409
    Dimorpholamine 119-48-2 98%
    Dimorpholamine (1064 Th) is a central nervous system stimulant. Dimorpholamine can increase the excitatory and inhibitory junction potentials at the neuromuscular junctions of crayfish. Dimorpholamine can also exert epinephrine-like pressor effects by promoting the release of catecholamines (mainly epinephrine) from the adrenal medulla. Dimorpholamine can be used in the research of respiratory failure as well as neurological and cardiovascular system diseases.
    Dimorpholamine
  • HY-W686216
    VK-28 312611-92-0
    VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease.
    VK-28
  • HY-W686762
    m,p-Dimethyl PPE 219704-16-2 98%
    m,p-Dimethyl PPE is a D4 dopamine receptor ligand. m,p-Dimethyl PPE promotes GDP/GTP exchange of the G protein α-subunit, dissociates the receptor-G protein complex, stabilizes the low-affinity receptor state, and inhibits adenylate cyclase activity. m,p-Dimethyl PPE inhibits Forskolin (HY-15371)-induced melatonin synthesis in retinal photoreceptor cells and reduces the efficacy of full agonists when used in combination. m,p-Dimethyl PPE can be used in studies related to attention-deficit hyperactivity disorder.
    m,p-Dimethyl PPE
  • HY-W698445
    α-Nicotine 23950-04-1 98%
    α-Nicotine is the α-isomer of Nicotine. Nicotine is a nicotinic acetylcholine receptor (nAChR) agonist. Nicotine is promising for research of neuropsychiatric disorders (e.g., schizophrenia, ADHD).
    α-Nicotine
  • HY-W699983
    Imidazole-15N2 74362-46-2 98.56%
    Imidazole-15N2 (Glyoxaline-15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
    Imidazole-15N2
  • HY-W700174
    3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium 1346603-21-1 98%
    3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium is an inactive metabolite of the GABAB receptor agonist Baclofen (HY-B0007).
    3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium
  • HY-W700204
    N-(p-Aminophenethyl)spiperone 93801-18-4 98%
    N-(p-Aminophenethyl) spiperone is a selective D2-like dopamine receptor antagonist. N-(p-Aminophenethyl) spiperone binds to the ligand recognition sites of functional D2 and D3 dopamine receptors. N-(p-Aminophenethyl) spiperone serves as a research tool compound for labeling, localizing and identifying D2 and D3 dopamine receptors.
    N-(p-Aminophenethyl)spiperone
  • HY-W700598
    Pipotiazine palmitate 37517-26-3 98%
    Pipotiazine palmitate is a dopamine receptor antagonist. Pipotiazine palmitate is a long-acting phenothiazine antipsychotic agent that can be administered by intramuscular injection. Pipotiazine palmitate can be used in the research of mental illnesses such as schizophrenia.
    Pipotiazine palmitate
  • HY-W700639
    Tolafentrine 139308-65-9 98%
    Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes.
    Tolafentrine
  • HY-W700834
    Harman-d3 1216708-84-7 98%
    Harman-d3 is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).
    Harman-d3
  • HY-W700993
    Dibucaine-d9 hydrochloride 1215713-38-4 98%
    Dibucaine-d9 hydrochloride (Cinchocaine-d9 hydrochloride) is the deuterium labeled Dibucaine hydrochloride (HY-B0552A). Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.
    Dibucaine-d9 hydrochloride
  • HY-W701743
    3,4-Dihydroxyamphetamine hydrochloride 828-06-8 98%
    3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure.
    3,4-Dihydroxyamphetamine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity